Martin Vokurka, MD, PhD
associate professor

Department of Pathological Physiology
First Faculty of Medicine
Charles University in Prague
Czech Republic

Contact

Curriculum vitae
Teaching
Research
Publications
Czech medical dictionaries
French for physicians

Curriculum vitae

• born 17/10/1962 in Prague (Czech Republic, form. Czechoslovakia)
• 1987 MD (Medical Faculty of Charles University, Prague)
• 1997 CSc. (PhD) - study of porphyrin metabolism
• 2005 associate professor of pathological physiology
• clinical experience in internal medicine
• 1994-96 INSERM U.82 (Paris, France) - research on mycobacteria and sarcoidosis
• Vice-Dean for Theoretical and Pre-clinical Education of the First Faculty of Medicine, Charles University in Prague) - from Sept 1st, 2008

Teaching

• 1982-83: anatomy (as undergraduate student during the anatomical dissections)
• 1983-87: pathophysiology (as undergraduate student during the practical trainings)
• from 1987 pathophysiology as PhD student, assistant professor and associate professor (since 2005)
• deputy head of the department for teaching
• courses in Czech and English, mainly pathophysiology of cardiovascular system, liver, metabolism (iron, porphyrins)
• author and co-authors of Czech textbooks of pathophysiology

Research

• senior researcher of the Center for Experimental Hematology, involved in the study of iron metabolism and its regulation, mainly the role of hepcidin
• previous topics: metabolism of porphyrins, experimental porphyrias, PCR detection of Mycobacteria (methodology, studies in sarcoidosis), cytofluorimetric detection of apoptosis

Publications

Main original papers

• Hugo J., Krijt J., Vokurka M., Janoušek V. Secretory Response to Light in Rat Harderian Gland: Possible Photoprotective Role of Harderian Porphyrin. General Physiology and Biophysics, 1987, vol. 6, p. 401-404.
• Hugo J., Vokurka M., Sanitrák J., Mělková Z., Janoušek V. First demonstration of porphyrins in the lacrimal glands: Similarity to the Harderian gland. Biomed. Biochim. Acta, 1989, vol. 48, p. K1-K4.
• Krijt J., Sanitrák J., Vokurka M., Janoušek V. Liver High Performance Liquid Chromatographic Porphyrin Profiles in Experimental Porphyria Induced by Peroxidizing Herbicides. Biomed. Chromatography, 1991, vol. 5, p. 38-42.
• Mangiapan G., Vokurka M., Schouls L., Cadranel J., Lecossier D., van Embden J., Hance A. J. Sequence capture-PCR improves the detection of mycobacterial DNA in clinical specimens. J. Clin. Microb., 1996, vol. 34, p. 1209-1215.
• Brugiere O., Vokurka M., Lecossier D., Mangiapan G., Amrane A., Milleron B., Mayaud C., Cadranel B., Hance A. J. Diagnosis of smear-negative pulmonary tuberculosis using sequence capture - PCR. Am. J. Respir. Crit. Care Med., 1997, vol. 155, p. 1478-1481.
• Vokurka M., Lecossier D., du Bois R. M., Wallaert B., Kambouchner M., Tazi A., Hance A. J. Absence of DNA from Mycobacteria of the M. Tuberculosis Complex in Sarcoidosis. Am. J. Respir. Crit. Care Med., 1997, vol. 156, s. 1000-1003.
• Bonay M., Bouchonnet F., Pelicic V., Lagier B., Grandsaigne M., Lecossier D., Grodet A., Vokurka M., Gicquel B. and Hance A. J. Effect of Stimulation of Human Macrophages on Intracellular Survival of Mycobacterium bovis Bacillus Calmette-Guerin. Evaluation with a Mycobacterial Reporter Strain. Am. J. Respir. Crit. Care Med., 1999, vol. 159, p. 1629-1637.
• Humlová Z., Vokurka, M., Esteban, M., and Mělková, Z. Vaccinia virus induces apoptosis of infected macrophages. J. of General Virology, 2002, vol. 83, p. 2821-2832.
• Krijt J, Pšenák O, Vokurka M, Chlumská A, Fakan F.: Experimental hepatic uroporphyria induced by the diphenyl-ether herbicide fomesafen in male DBA/2 mice. Toxicol Appl Pharmacol., 2003, no. 1, vol. 189, p. 28-38.
• Krijt J., Čmejla R., Sýkora V., Vokurka M., Vyoral D., Nečas E. Different expression pattern of hepcidin genes in the liver and pancreas of C57BL/6N and DBA/2N mice. J Hepatol., 2004, vol. 40, p. 891-896
• Krijt J., Vokurka M., Chang K.T., Nečas E.: Expression of Rgmc, the murine ortholog of hemojuvelin gene, is modulated by development and inflammation, but not by iron status or erythropoietin. Blood, 2004, vol. 104, p. 4308-4310
• Ko-Tung Chang, Šefc L., Pšenák O., Vokurka M., Nečas E.: Early fetal liver readily repopulates B-lymphopoiesis in adult bone marrow. Stem Cells, 2005, vol. 23, p. 230-239
• Vokurka M., Krijt J., Šulc K., Nečas E.: Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis. Physiol. Res. , 2006, vol. 55, p. 667-674 (prepublished on-line in February 2006)
• Krijt J., Vokurka M., Šefc L., Ďuricová D., Nečas E.: Effect of Lipopolysaccharide and Bleeding on the Expression of Intestinal Proteins Involved in Iron and Haem Transport. Folia Biologica, 2006, vol. 52, p. 1-5
• Křemen J., Dolinková M., Krajíčkova J., Bláha J., Anderlová K., Lacinová Z., Haluzíková D., Bosanská L., Vokurka M., Svačina Š. and Haluzík M.: Increased subcutaneous and epicardial adipose tissue production of proinflammatory cytokines in cardiac surgery patients: possible role in postoperative insulin resistance. J Clin Endocrin Metab. , 2006, vol. 91(11): 4620-4627. First published ahead of print August 8, 2006 as doi:10.1210/jc.2006-1044
• Krijt J., Niederkofler V., Salie R., Šefc L., Pelichovská T., Vokurka M., Nečas E.: Effect of phlebotomy on hepcidin expression in hemojuvelin-mutant mice. Blood Cells Mol Dis., 2007 Jul-Aug;39(1):92-5. Epub 2007 Mar 28
• Fujikura Y., Kudlackova P., Vokurka M., Krijt J., Melkova Z.: The effect of nitric oxide on vaccinia virus-encoded ribonucleotide reductase. Nitric Oxide, 2009 Mar;20(2):114-121
• Krijt J., Fujikura Y., Sefc L., Vokurka M., Hlobeňová T., Nečas E.: Hepcidin downregulation by repeated bleeding is not mediated by soluble hemojuvelin. Physiol. Res., 2009 Feb 27. [Epub ahead of print]
• Vokurka M., Lacinová Z., Křemen J., Kopecký P., Bláha J., Pelinková K., Haluzík M., Nečas E.: Hepcidin expression in adipose tissue increases during cardiac surgery. Physiol. Res., 2009 Aug 12. [Epub ahead of print]

Czech Medical Dictionaries

I am one of the principal co-authors of the Czech medical dictionaries. These dictionaries are published from 1994 by the Maxdorf publishing house. The latest (9th) edition of the Great Medical Dictionary ("Velký lékařský slovník") has over 40,000 entries and over 1,069 pages and was published in the end of 2009.

Francouzština pro lékaře (French for Physicians, Francais pour les médecins)

This paperback by R. Rokyta, R. Stejskal and M. Vokurka was published in October 2007by Grada Publishing. It is a practical book for Czech doctors or medical students who come to France and other French speaking countries or to the French who come to the Czech Republic (e.g. Erasmus students).

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